| Players Picked at #221 | ||||||||||
| Season | Pick # | Team | Name | Position | College | |||||
| 2025 | 221 | Jacksonville Jaguars | Jonah Monheim | C | USC | |||||
| 2024 | 221 | Buffalo Bills | Travis Clayton | G | England | |||||
| 2023 | 221 | Indianapolis Colts | Jaylon Jones | CB | Texas A&M | |||||
| 2022 | 221 | San Francisco 49ers | Tariq Castro-Fields | CB | Penn State | |||||
| 2021 | 221 | Chicago Bears | Dazz Newsome | WR | North Carolina | |||||
| 2020 | 221 | Carolina Panthers | Stantley Thomas-Oliver III | CB | Florida International | |||||
| 2019 | 221 | Cleveland Browns | Donnie Lewis Jr. | CB | Tulane | |||||
| 2018 | 221 | Indianapolis Colts | Matthew Adams | LB | Houston | |||||
| 2017 | 221 | Oakland Raiders | Shalom Luani | S | Washington State | |||||
| 2016 | 221 | New England Patriots | Ted Karras III | G | Illinois | |||||
| 2015 | 221 | Oakland Raiders | Andre Debose | WR | Florida | |||||
| 2014 | 221 | Buffalo Bills | Randell Johnson | LB | Florida Atlantic | |||||
| 2013 | 221 | San Diego Chargers | Brad Sorensen | QB | Southern Utah | |||||
| 2012 | 221 | Arizona Cardinals | Nate Potter | T | Boise State | |||||
| 2011 | 221 | New York Giants | Da'Rel Scott | RB | Maryland | |||||
| 2010 | 221 | New York Giants | Matt Dodge | P | East Carolina | |||||
| 2009 | 221 | Washington Redskins | Eddie Williams | TE | Idaho | |||||
| 2008 | 221 | Carolina Panthers | Hilee Taylor | LB | North Carolina | |||||
| 2007 | 221 | Chicago Bears | Trumaine McBride | CB | Mississippi | |||||
| 2006 | 221 | St Louis Rams | Tim McGarigle | LB | Northwestern | |||||
| 2005 | 221 | Tampa Bay Buccaneers | Rick Razzano | FB | Mississippi | |||||
| 2004 | 221 | Miami Dolphins | Tony Pape | T | Michigan | |||||
| 2003 | 221 | Minnesota Vikings | Keenan Howry | WR | Oregon | |||||
| 2002 | 221 | Kansas City Chiefs | Maurice Rodriguez | LB | Fresno State | |||||
| 2001 | 221 | New Orleans Saints | Ennis Davis | DT | USC | |||||
| 2000 | 221 | Carolina Panthers | Lester Towns | LB | Washington | |||||
| 1999 | 221 | Chicago Bears | Sulecio Sanford | WR | Middle Tennessee State | |||||
| 1998 | 221 | Pittsburgh Steelers | Angel Rubio | DT | Southeast Missouri State | |||||
| 1997 | 221 | Jacksonville Jaguars | Jon Hesse | LB | Nebraska | |||||
| 1996 | 221 | Tampa Bay Buccaneers | Reggie Rusk | CB | Kentucky | |||||
| 1995 | 221 | Buffalo Bills | Tom N?tten | C | Western Michigan | |||||
| 1994 | 221 | Buffalo Bills | Filmel Johnson | DB | Illinois | |||||
| 1993 | 221 | New Orleans Saints | Jon Kirksey | DT | Cal State-Sacramento | |||||
| 1992 | 221 | Detroit Lions | Willie Clay | S | Georgia Tech | |||||
| 1991 | 221 | San Francisco 49ers | Tony Hargain | WR | Oregon Tech | |||||
| 1990 | 221 | Dallas Cowboys | Kenneth Gant | DB | Albany State | |||||
| 1989 | 221 | Chicago Bears | Chris Dyko | T | Washington State | |||||
| 1988 | 221 | Washington Redskins | Darryl McGill | RB | Wake Forest | |||||
| 1987 | 221 | Chicago Bears | Paul Migliazzo | LB | Oklahoma | |||||
| 1986 | 221 | Chicago Bears | Maurice Douglass | DB | Kentucky | |||||
| 1985 | 221 | Seattle Seahawks | Judious Lewis | WR | Arkansas State | |||||
| 1984 | 221 | Miami Dolphins | Ronnie Landry | RB | McNeese State | |||||
| 1983 | 221 | Cincinnati Bengals | Mike Martin | WR | Illinois | |||||
| 1982 | 221 | Dallas Cowboys | Dwight Sullivan | RB | North Carolina State | |||||
| 1981 | 221 | New York Giants | Bill Ard | G | Wake Forest | |||||
| 1980 | 221 | Pittsburgh Steelers | Ted Walton | DB | Connecticut | |||||
| 1979 | 221 | San Francisco 49ers | Steve Hamilton | DT | Missouri | |||||
| 1978 | 221 | Denver Broncos | Frank Smith | T | Alabama A&M | |||||
| 1977 | 221 | Dallas Cowboys | Fred Williams | RB | Arizona State | |||||
| 1976 | 221 | New York Giants | John Jordan | DT | Indiana | |||||
| 1975 | 221 | Houston Oilers | Bob Bruer | TE | Mankato State | |||||
| 1974 | 221 | Los Angeles Rams | Derek Williams | DB | California-Riverside | |||||
| 1973 | 221 | Minnesota Vikings | Larry Dibbles | DE | New Mexico | |||||
| 1972 | 221 | San Diego Chargers | Fran Schmitz | DT | St. Norbert | |||||
| 1971 | 221 | San Diego Chargers | John Tanner | TE | Tennessee Tech | |||||
| 1970 | 221 | New York Giants | Pat Hughes | C | Boston Univ. | |||||
| 1969 | 221 | Houston Oilers | Ed Watson | LB | Grambling State | |||||
| 1968 | 221 | Atlanta Falcons | Henry Holland | C | North Texas | |||||
| 1967 | 221 | Chicago Bears | Greg Cass | C | Washington | |||||
| 1966 | 221 | Washington Redskins | Hal Seymour | RB | Florida | |||||
| 1965 | 221 | Detroit Lions | John Smith | T | Maryland-Eastern Shore | |||||
| 1964 | 221 | New York Giants | Wynn Lembright | T | Toledo | |||||
| 1963 | 221 | Chicago Bears | Lowell Caylor | DB | Miami (OH) | |||||
| 1962 | 221 | Cleveland Browns | Dennis Biodrowski | E | Memphis | |||||
| 1961 | 221 | New York Giants | Bernie Vishneski | T | Virginia Tech | |||||
| 1960 | 221 | Green Bay Packers | Rich Brooks | E | Purdue | |||||
| 1959 | 221 | Detroit Lions | Rufus Granderson | T | Prairie View | |||||
| 1958 | 221 | Chicago Bears | Bill Chancey | E | West Virginia | |||||
| 1957 | 221 | Pittsburgh Steelers | Phil Bennett | E | Miami (FL) | |||||
| 1956 | 221 | Chicago Cardinals | Ray Zagar | B | Marquette | |||||
| 1955 | 221 | Green Bay Packers | Bob Carter | T | Grambling State | |||||
| 1954 | 221 | Baltimore Colts | Charley Wenzlau | E | Miami (OH) | |||||
| 1953 | 221 | Pittsburgh Steelers | Jim Williams | B | Louisville | |||||
| 1952 | 221 | Philadelphia Eagles | Talbott Trammell | E | Washington & Lee | |||||
| 1951 | 221 | Washington Redskins | Buddy Brown | G | Arkansas | |||||
| 1950 | 221 | Cleveland Browns | Hal McKinney | G | Missouri Valley | |||||
| 1949 | 221 | Philadelphia Eagles | Harvey Kingry | B | Colorado Mines | |||||
| 1948 | 221 | Green Bay Packers | Clyde Biggers | T | Catawba | |||||
| 1947 | 221 | Philadelphia Eagles | Stanton Hense | E | Xavier | |||||
| 1946 | 221 | Chicago Cardinals | Jack McKenzie | B | Northwestern | |||||
| 1945 | 221 | Pittsburgh Steelers | Don Malmberg | B | UCLA | |||||
| 1944 | 221 | Brooklyn Tigers | Ted Cook | E | Alabama | |||||
| 1943 | 221 | Detroit Lions | Will Remington | C | Washington State | |||||