| Players Picked at #2 | ||||||||||
| Season | Pick # | Team | Name | Position | College | |||||
| 2025 | 2 | Jacksonville Jaguars | Travis Hunter | CB | Colorado | |||||
| 2024 | 2 | Washington Commanders | Jayden Daniels | QB | LSU | |||||
| 2023 | 2 | Houston Texans | C. J. Stroud | QB | Ohio State | |||||
| 2022 | 2 | Detroit Lions | Aidan Hutchinson | DE | Michigan | |||||
| 2021 | 2 | New York Jets | Zach Wilson | QB | BYU | |||||
| 2020 | 2 | Washington Football Team | Chase Young | DE | Ohio State | |||||
| 2019 | 2 | San Francisco 49ers | Nick Bosa | DE | Ohio State | |||||
| 2018 | 2 | New York Giants | Saquon Barkley | RB | Penn State | |||||
| 2017 | 2 | Chicago Bears | Mitchell Trubisky | QB | North Carolina | |||||
| 2016 | 2 | Philadelphia Eagles | Carson Wentz | QB | North Dakota State | |||||
| 2015 | 2 | Tennessee Titans | Marcus Mariota | QB | Oregon | |||||
| 2014 | 2 | St Louis Rams | Greg Robinson | T | Auburn | |||||
| 2013 | 2 | Jacksonville Jaguars | Luke Joeckel | T | Texas A&M | |||||
| 2012 | 2 | Washington Redskins | Robert Griffin III | QB | Baylor | |||||
| 2011 | 2 | Denver Broncos | Von Miller | LB | Texas A&M | |||||
| 2010 | 2 | Detroit Lions | Ndamukong Suh | DT | Nebraska | |||||
| 2009 | 2 | St Louis Rams | Jason Smith | T | Baylor | |||||
| 2008 | 2 | St Louis Rams | Chris Long | DE | Virginia | |||||
| 2007 | 2 | Detroit Lions | Calvin Johnson | WR | Georgia Tech | HOF - 2021 | ||||
| 2006 | 2 | New Orleans Saints | Reggie Bush | RB | USC | |||||
| 2005 | 2 | Miami Dolphins | Ronnie Brown | RB | Auburn | |||||
| 2004 | 2 | Oakland Raiders | Robert Gallery | T | Iowa | |||||
| 2003 | 2 | Detroit Lions | Charles Rogers | WR | Michigan State | |||||
| 2002 | 2 | Carolina Panthers | Julius Peppers | DE | North Carolina | HOF - 2024 | ||||
| 2001 | 2 | Arizona Cardinals | Leonard Davis | G | Texas | |||||
| 2000 | 2 | Washington Redskins | LaVar Arrington | LB | Penn State | |||||
| 1999 | 2 | Philadelphia Eagles | Donovan McNabb | QB | Syracuse | |||||
| 1998 | 2 | San Diego Chargers | Ryan Leaf | QB | Washington State | |||||
| 1997 | 2 | Oakland Raiders | Darrell Russell | DT | USC | |||||
| 1996 | 2 | Jacksonville Jaguars | Kevin Hardy | LB | Illinois | |||||
| 1995 | 2 | Jacksonville Jaguars | Tony Boselli | T | USC | HOF - 2022 | ||||
| 1994 | 2 | Indianapolis Colts | Marshall Faulk | RB | San Diego State | HOF - 2011 | ||||
| 1993 | 2 | Seattle Seahawks | Rick Mirer | QB | Notre Dame | |||||
| 1992 | 2 | Indianapolis Colts | Quentin Coryatt | LB | Texas A&M | |||||
| 1991 | 2 | Cleveland Browns | Eric Turner | S | UCLA | |||||
| 1990 | 2 | New York Jets | Blair Thomas | RB | Penn State | |||||
| 1989 | 2 | Green Bay Packers | Tony Mandarich | T | Michigan State | |||||
| 1988 | 2 | Kansas City Chiefs | Neil Smith | DE | Nebraska | |||||
| 1987 | 2 | Indianapolis Colts | Cornelius Bennett | OLB | Alabama | |||||
| 1986 | 2 | Atlanta Falcons | Tony Casillas | NT | Oklahoma | |||||
| 1985 | 2 | Atlanta Falcons | Bill Fralic | G | Pittsburgh | |||||
| 1984 | 2 | Houston Oilers | Dean Steinkuhler | T | Nebraska | |||||
| 1983 | 2 | Los Angeles Rams | Eric Dickerson | RB | SMU | HOF - 1999 | ||||
| 1982 | 2 | Baltimore Colts | Johnie Cooks | OLB | Mississippi State | |||||
| 1981 | 2 | New York Giants | Lawrence Taylor | LB | North Carolina | HOF - 1999 | ||||
| 1980 | 2 | New York Jets | Johnny Lam Jones | WR | Texas | |||||
| 1979 | 2 | Kansas City Chiefs | Mike Bell | DE | Colorado State | |||||
| 1978 | 2 | Kansas City Chiefs | Art Still | DE | Kentucky | |||||
| 1977 | 2 | Dallas Cowboys | Tony Dorsett | RB | Pittsburgh | HOF - 1994 | ||||
| 1976 | 2 | Seattle Seahawks | Steve Niehaus | DT | Notre Dame | |||||
| 1975 | 2 | Dallas Cowboys | Randy White | DT | Maryland | HOF - 1994 | ||||
| 1974 | 2 | San Diego Chargers | Bo Matthews | RB | Colorado | |||||
| 1973 | 2 | Baltimore Colts | Bert Jones | QB | LSU | |||||
| 1972 | 2 | Cincinnati Bengals | Sherman White | DE | California | |||||
| 1971 | 2 | New Orleans Saints | Archie Manning | QB | Mississippi | |||||
| 1970 | 2 | Green Bay Packers | Mike P. McCoy | DT | Notre Dame | |||||
| 1969 | 2 | Atlanta Falcons | George Kunz | T | Notre Dame | |||||
| 1968 | 2 | Cincinnati Bengals | Bob Johnson | C | Tennessee | |||||
| 1967 | 2 | Minnesota Vikings | Clint Jones | RB | Michigan State | |||||
| 1966 | 2 | Los Angeles Rams | Tom Mack | T | Michigan | HOF - 1999 | ||||
| 1965 | 2 | San Francisco 49ers | Ken Willard | FB | North Carolina | |||||
| 1964 | 2 | Philadelphia Eagles | Bob Brown | T | Nebraska | |||||
| 1963 | 2 | St. Louis Cardinals | Jerry Stovall | B | LSU | |||||
| 1962 | 2 | Los Angeles Rams | Roman Gabriel | QB | North Carolina State | |||||
| 1961 | 2 | Washington Redskins | Norm Snead | QB | Wake Forest | |||||
| 1960 | 2 | St. Louis Cardinals | George Izo | QB | Notre Dame | |||||
| 1959 | 2 | Los Angeles Rams | Dick Bass | RB | Pacific | |||||
| 1958 | 2 | Chicago Cardinals | John David Crow | HB | Texas A&M | |||||
| 1957 | 2 | Los Angeles Rams | Jon Arnett | HB | USC | |||||
| 1956 | 2 | San Francisco 49ers | Earl Morrall | QB | Michigan State | |||||
| 1955 | 2 | Chicago Cardinals | Max Boydston | E | Oklahoma | |||||
| 1954 | 2 | Chicago Cardinals | Lamar McHan | QB | Arkansas | |||||
| 1953 | 2 | Baltimore Colts | Billy Vessels | HB | Oklahoma | |||||
| 1952 | 2 | Dallas Texans | Les Richter | G | California | HOF - 2011 | ||||
| 1951 | 2 | Chicago Bears | Bob Williams | QB | Notre Dame | |||||
| 1950 | 2 | Baltimore Colts | Adrian Burk | QB | Baylor | |||||
| 1949 | 2 | Detroit Lions | Johnny Rauch | QB | Georgia | |||||
| 1948 | 2 | New York Giants | Tony Minisi | HB | Pennsylvania | |||||
| 1947 | 2 | Detroit Lions | Glenn Davis | HB | Army | |||||
| 1946 | 2 | Chicago Cardinals | Dub Jones | B | Tulane | |||||
| 1945 | 2 | Pittsburgh Steelers | Paul Duhart | HB | Florida | |||||
| 1944 | 2 | Chicago Cardinals | Pat Harder | FB | Wisconsin | |||||
| 1943 | 2 | Phil-Pitt Steagles | Joe Muha | FB | Virginia Military | |||||
| 1942 | 2 | Cleveland Rams | Jack Wilson | FB | Baylor | |||||
| 1941 | 2 | Chicago Cardinals | John Kimbrough | FB | Texas A&M | |||||
| 1940 | 2 | Philadelphia Eagles | George McAfee | QB | Duke | HOF - 1966 | ||||
| 1939 | 2 | Chicago Bears | Sidney Luckman | QB | Columbia | HOF - 1965 | ||||
| 1938 | 2 | Philadelphia Eagles | Jim McDonald | B | Ohio State | |||||
| 1937 | 2 | Brooklyn Dodgers | Ed Goddard | B | Washington State | |||||
| 1936 | 2 | Boston Redskins | Riley Smith | QB | Alabama | |||||